The Akt Forkhead Box O Transcription Factor Axis Regulates Human Cytomegalovirus Replication

The Akt Forkhead Box O Transcription Factor Axis Regulates Human Cytomegalovirus Replication

ABSTRACT The protein kinase Akt broadly impacts many cellular processes, including mRNA translation, metabolism, apoptosis, and stress responses. Inhibition of phosphatidylinositol 3-kinase (PI3K), a lipid kinase pivotal to Akt activation, triggers various herpesviruses to reactivate from latency. H...

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Bibliographic Details
Main Authors: Hongbo Zhang, Anthony J. Domma, Felicia D. Goodrum, Nathaniel J. Moorman, Jeremy P. Kamil
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
AKT signaling
cytomegalovirus
herpesviruses
human herpesviruses
metabolism
protein kinases
Online Access:https://journals.asm.org/doi/10.1128/mbio.01042-22

Internet

https://journals.asm.org/doi/10.1128/mbio.01042-22

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