An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver

An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter β-TrCP delivers anti-inflammatory responses in mouse liver

It is widely accepted that activating the transcription factor NRF2 will blast the physiological anti-inflammatory mechanisms, which will help combat pathologic inflammation. Much effort is being put in inhibiting the main NRF2 repressor, KEAP1, with either electrophilic small molecules or disrupter...

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Bibliographic Details
Main Authors: Raquel Fernández-Ginés, José Antonio Encinar, John D. Hayes, Baldo Oliva, Maria Isabel Rodríguez-Franco, Ana I. Rojo, Antonio Cuadrado
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Redox Biology
Subjects:
NRF2
β-TrCP
Protein-protein interaction inhibitor
Inflammation
Liver
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722001689

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http://www.sciencedirect.com/science/article/pii/S2213231722001689

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