Highly sensitive noninvasive early lung cancer detection using DNA methylation topology in sputum-derived epithelial cellsCentral MessagePerspective

Highly sensitive noninvasive early lung cancer detection using DNA methylation topology in sputum-derived epithelial cellsCentral MessagePerspective

Objective: Sputum is a source of exfoliated respiratory epithelial cells transformed early in lung carcinogenesis. Malignant cells are hypomethylated and contain less genomic 5-methylcytosine (5mC). Validating a test that recognizes and quantifies aberrantly hypomethylated cells in sputum, we assess...

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Bibliographic Details
Main Authors: Harmik J. Soukiasian, MD, Alexander Leung, MD, Taryne Imai, MD, Shika Bose, MD, Sungjin Kim, MS, Zab Mosenifar, MD, Nirdesh K. Gupta, PhD, Jian Tajbakhsh, PhD
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:JTCVS Open
Subjects:
DNA methylation
noninvasive test
non–small cell lung cancer
screening
sputum
Online Access:http://www.sciencedirect.com/science/article/pii/S2666273622004156

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http://www.sciencedirect.com/science/article/pii/S2666273622004156

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