Highly sensitive noninvasive early lung cancer detection using DNA methylation topology in sputum-derived epithelial cellsCentral MessagePerspective
Objective: Sputum is a source of exfoliated respiratory epithelial cells transformed early in lung carcinogenesis. Malignant cells are hypomethylated and contain less genomic 5-methylcytosine (5mC). Validating a test that recognizes and quantifies aberrantly hypomethylated cells in sputum, we assess...
Main Authors: | Harmik J. Soukiasian, MD, Alexander Leung, MD, Taryne Imai, MD, Shika Bose, MD, Sungjin Kim, MS, Zab Mosenifar, MD, Nirdesh K. Gupta, PhD, Jian Tajbakhsh, PhD |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2023-03-01
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Series: | JTCVS Open |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2666273622004156 |
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