Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain

Phosphonate Inhibitors of Pyruvate Dehydrogenase Perturb Homeostasis of Amino Acids and Protein Succinylation in the Brain

Mitochondrial pyruvate dehydrogenase complex (PDHC) is essential for brain glucose and neurotransmitter metabolism, which is dysregulated in many pathologies. Using specific inhibitors of PDHC in vivo, we determine biochemical and physiological responses to PDHC dysfunction. Dose dependence of the r...

Full description

Bibliographic Details
Main Authors: Artem V. Artiukhov, Vasily A. Aleshin, Irina S. Karlina, Alexey V. Kazantsev, Daria A. Sibiryakina, Alexander L. Ksenofontov, Nikolay V. Lukashev, Anastasia V. Graf, Victoria I. Bunik
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
branched chain 2-oxo acids
2-oxoglutarate dehydrogenase
pyruvate dehydrogenase
phosphonate and phosphinate analogs of pyruvate
protein succinylation
protein acetylation
Online Access:https://www.mdpi.com/1422-0067/23/21/13186

Internet

https://www.mdpi.com/1422-0067/23/21/13186

Similar Items