Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis

Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis

The P53 pathway is the most important cellular pathway to maintain genomic and cellular integrity, both in embryonic and non-embryonic cells. Stress signals induce its activation, initiating autophagy or cell cycle arrest to enable DNA repair. The persistence of these signals causes either senescenc...

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Bibliographic Details
Main Authors: Dennis M. Timmerman, Tessa L. Remmers, Sanne Hillenius, Leendert H. J. Looijenga
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
P53 pathway
cancers
mutations
embryonic and somatic cells
Online Access:https://www.mdpi.com/1422-0067/22/10/5377

Internet

https://www.mdpi.com/1422-0067/22/10/5377

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