Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity

Permanent neonatal diabetes-causing insulin mutations have dominant negative effects on beta cell identity

Objective: Heterozygous coding sequence mutations of the INS gene are a cause of permanent neonatal diabetes (PNDM), requiring insulin therapy similar to T1D. While the negative effects on insulin processing and secretion are known, how dominant insulin mutations result in a continued decline of bet...

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Bibliographic Details
Main Authors: Yuwei Zhang, Lina Sui, Qian Du, Leena Haataja, Yishu Yin, Ryan Viola, Shuangyi Xu, Christian Ulrik Nielsson, Rudolph L. Leibel, Fabrizio Barbetti, Peter Arvan, Dieter Egli
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Molecular Metabolism
Subjects:
Insulin
ER stress
iPS cells
Gene correction
Cell therapy
Beta cell de-differentiation
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824000103

Internet

http://www.sciencedirect.com/science/article/pii/S2212877824000103

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