The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.

<h4>Background</h4>Sensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock. Highly nonlinear kinetics a...

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Main Authors: Treenut Saithong, Kevin J Painter, Andrew J Millar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-11-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21152419/?tool=EBI
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author Treenut Saithong
Kevin J Painter
Andrew J Millar
author_facet Treenut Saithong
Kevin J Painter
Andrew J Millar
author_sort Treenut Saithong
collection DOAJ
description <h4>Background</h4>Sensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock. Highly nonlinear kinetics and multiple loops are often incorporated into models to match experimental time-series data, but these also impact on model properties for clock models.<h4>Methodology/principal findings</h4>Here, we study the consequences of complicated structure and nonlinearity using simple Goodwin-type oscillators and the complex Arabidopsis circadian clock models. Sensitivity analysis of the simple oscillators implies that an interlocked multi-loop structure reinforces sensitivity/robustness properties, enhancing the response to external and internal variations. Furthermore, we found that reducing the degree of nonlinearity could sometimes enhance the robustness of models, implying that ad hoc incorporation of nonlinearity could be detrimental to a model's perceived credibility.<h4>Conclusion</h4>The correct multi-loop structure and degree of nonlinearity are therefore critical in contributing to the desired properties of a model as well as its capacity to match experimental data.
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spelling doaj.art-8fcef2ebf1fa46cc9ef01315fd7894642022-12-21T20:34:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-11-01511e1386710.1371/journal.pone.0013867The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.Treenut SaithongKevin J PainterAndrew J Millar<h4>Background</h4>Sensitivity and robustness are essential properties of circadian clock systems, enabling them to respond to the environment but resist noisy variations. These properties should be recapitulated in computational models of the circadian clock. Highly nonlinear kinetics and multiple loops are often incorporated into models to match experimental time-series data, but these also impact on model properties for clock models.<h4>Methodology/principal findings</h4>Here, we study the consequences of complicated structure and nonlinearity using simple Goodwin-type oscillators and the complex Arabidopsis circadian clock models. Sensitivity analysis of the simple oscillators implies that an interlocked multi-loop structure reinforces sensitivity/robustness properties, enhancing the response to external and internal variations. Furthermore, we found that reducing the degree of nonlinearity could sometimes enhance the robustness of models, implying that ad hoc incorporation of nonlinearity could be detrimental to a model's perceived credibility.<h4>Conclusion</h4>The correct multi-loop structure and degree of nonlinearity are therefore critical in contributing to the desired properties of a model as well as its capacity to match experimental data.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21152419/?tool=EBI
spellingShingle Treenut Saithong
Kevin J Painter
Andrew J Millar
The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
PLoS ONE
title The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
title_full The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
title_fullStr The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
title_full_unstemmed The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
title_short The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models.
title_sort contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models
url https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21152419/?tool=EBI
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