Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis.

Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis.

Theta-defensins (θ-defensins) are macrocyclic antimicrobial peptides expressed in leukocytes of Old World monkeys. The peptides are broad spectrum microbicides in vitro and numerous θ-defensin isoforms have been identified in granulocytes of rhesus macaques and Olive baboons. Several mammalian α- an...

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Bibliographic Details
Main Authors: Justin B Schaal, Dat Tran, Patti Tran, George Ösapay, Katie Trinh, Kevin D Roberts, Kathleen M Brasky, Prasad Tongaonkar, André J Ouellette, Michael E Selsted
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3516535?pdf=render

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http://europepmc.org/articles/PMC3516535?pdf=render

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