Functional Interaction Between the Oncogenic Kinase NEK2 and Sam68 Promotes a Splicing Program Involved in Migration and Invasion in Triple-Negative Breast Cancer

Functional Interaction Between the Oncogenic Kinase NEK2 and Sam68 Promotes a Splicing Program Involved in Migration and Invasion in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer subtype. Poor prognosis in TNBC is partly due to lack of efficacious targeted therapy and high propensity to metastasize. Dysregulation of alternative splicing has recently emerged as a trait of TNBC, suggesting that u...

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Bibliographic Details
Main Authors: Chiara Naro, Federica Barbagallo, Cinzia Caggiano, Monica De Musso, Valentina Panzeri, Silvia Di Agostino, Maria Paola Paronetto, Claudio Sette
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
triple-negative breast cancer
alternative splicing
transcriptomics
NEK2
SAM68
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.880654/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.880654/full

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