Pharmacology-based ranking of anti-cancer drugs to guide clinical development of cancer immunotherapy combinations

Abstract The success of antibodies targeting Programmed cell death protein 1 (PD-1) and its ligand L1 (PD-L1) in cancer treatment and the need for improving response rates has led to an increased demand for the development of combination therapies with anti-PD-1/PD-L1 blockers as a backbone. As more...

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Bibliographic Details
Main Authors: Vincent Lemaire, Colby S. Shemesh, Anand Rotte
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Online Access:https://doi.org/10.1186/s13046-021-02111-5