Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy

Mitofusin 1 silencing decreases the senescent associated secretory phenotype, promotes immune cell recruitment and delays melanoma tumor growth after chemotherapy

Abstract Cellular senescence is a therapy endpoint in melanoma, and the senescence-associated secretory phenotype (SASP) can affect tumor growth and microenvironment, influencing treatment outcomes. Metabolic interventions can modulate the SASP, and mitochondrial energy metabolism supports resistanc...

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Bibliographic Details
Main Authors: Doménica Tarallo, Jennyfer Martínez, Alejandro Leyva, Amy Mónaco, Carolina Perroni, Marcos Tassano, Juan Pablo Gambini, Mónica Cappetta, Rosario Durán, María Moreno, Celia Quijano
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-51427-7

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https://doi.org/10.1038/s41598-024-51427-7

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