CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVΔnef-induced protection.

CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVΔnef-induced protection.

The live attenuated simian immunodeficiency virus (LASIV) vaccine SIVΔnef is one of the most effective vaccines in inducing protection against wild-type lentiviral challenge, yet little is known about the mechanisms underlying its remarkable protective efficacy. Here, we exploit deep sequencing tech...

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Bibliographic Details
Main Authors: Sama Adnan, Arnaud D Colantonio, Yi Yu, Jacqueline Gillis, Fay E Wong, Ericka A Becker, Michael Piatak, R Keith Reeves, Jeffrey D Lifson, Shelby L O'Connor, R Paul Johnson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4334552?pdf=render

Internet

http://europepmc.org/articles/PMC4334552?pdf=render

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