The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

The PD-1 Pathway Regulates Development and Function of Memory CD8+ T Cells following Respiratory Viral Infection

Summary: The PD-1 pathway regulates dysfunctional T cells in chronic infection and cancer, but the role of this pathway during acute infection remains less clear. Here, we demonstrate that PD-1 signals are needed for optimal memory. Mice deficient in the PD-1 pathway exhibit impaired CD8+ T cell mem...

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Bibliographic Details
Main Authors: Kristen E. Pauken, Jernej Godec, Pamela M. Odorizzi, Keturah E. Brown, Kathleen B. Yates, Shin Foong Ngiow, Kelly P. Burke, Seth Maleri, Shannon M. Grande, Loise M. Francisco, Mohammed-Alkhatim Ali, Sabrina Imam, Gordon J. Freeman, W. Nicholas Haining, E. John Wherry, Arlene H. Sharpe
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
PD-1
PD-L1
PD-L2
checkpoint blockade
CD8+ T cell
acute infection
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720308081

Internet

http://www.sciencedirect.com/science/article/pii/S2211124720308081

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