Mesenchymal stem cells genetically engineered to express platelet-derived growth factor and heme oxygenase-1 ameliorate osteoarthritis in a canine model

Mesenchymal stem cells genetically engineered to express platelet-derived growth factor and heme oxygenase-1 ameliorate osteoarthritis in a canine model

Abstract Background Mesenchymal stem cells (MSCs) are used for the treatment of osteoarthritis (OA), and MSC genetic engineering is expected to enhance cartilage repair. Here, we aimed to investigate the effect of MSCs overexpressing platelet-derived growth factor (PDGF) or heme oxygenase-1 (HO-1) i...

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Bibliographic Details
Main Authors: Jiwon Oh, Yeon Sung Son, Wan Hee Kim, Oh-Kyeong Kwon, Byung-Jae Kang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Mesenchymal stem cells
Osteoarthritis
Platelet-derived growth factor
Heme oxygenase-1
Online Access:https://doi.org/10.1186/s13018-020-02178-4

Internet

https://doi.org/10.1186/s13018-020-02178-4

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