In-Depth Analysis of Human Neonatal and Adult IgM Antibody Repertoires

In-Depth Analysis of Human Neonatal and Adult IgM Antibody Repertoires

Although high-throughput sequencing and associated bioinformatics technologies have enabled the in-depth, sequence-based characterization of human immune repertoires, only a few studies on a relatively small number of sequences explored the characteristics of antibody repertoires in neonates, with c...

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Bibliographic Details
Main Authors: Binbin Hong, Yanling Wu, Wei Li, Xun Wang, Yumei Wen, Shibo Jiang, Dimiter S. Dimitrov, Tianlei Ying
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Immunology
Subjects:
high-throughput sequencing
antibody repertoire
cord blood
VDJ rearrangement
junctional modification
N2 addition
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00128/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00128/full

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