Structure and Function of Hoc—A Novel Environment Sensing Device Encoded by T4 and Other Bacteriophages

Structure and Function of Hoc—A Novel Environment Sensing Device Encoded by T4 and Other Bacteriophages

Bacteriophage T4 is decorated with 155 180 Å-long fibers of the highly antigenic outer capsid protein (Hoc). In this study, we describe a near-atomic structural model of Hoc by combining cryo-electron microscopy and AlphaFold structure predictions. It consists of a conserved C-terminal capsid-bindin...

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Bibliographic Details
Main Authors: Andrei Fokine, Mohammad Zahidul Islam, Qianglin Fang, Zhenguo Chen, Lei Sun, Venigalla B. Rao
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Viruses
Subjects:
bacteriophage T4
phage head structure
highly immunogenic outer capsid protein Hoc
capsid decoration protein
phage display
antigen display
Online Access:https://www.mdpi.com/1999-4915/15/7/1517

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https://www.mdpi.com/1999-4915/15/7/1517

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