Development and validation of an improved LC-MS/MS method for the quantification of desloratadine and its metabolite in human plasma using deutrated desloratadine as internal standard

Development and validation of an improved LC-MS/MS method for the quantification of desloratadine and its metabolite in human plasma using deutrated desloratadine as internal standard

Purpose: For the determination of desloratadine (DES) and 3-OH desloratadine (3-OHD) in human plasma using deutrated desloratadine (DESD5) as internal standard (IS), a novel stability indicating liquid chromatography-tandem mass spectrometric method was developed and validated to support the clinica...

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Bibliographic Details
Main Authors: M Saquib Hasnain, Shireen Rao, Manoj Kr. Singh, Nitin Vig, Manish Kr. Singh, Subodh Kr. Budakoti, Abdulla Ansari
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2013-01-01
Series:Journal of Pharmacy and Bioallied Sciences
Subjects:
Desloratadine
method validation
3-OH desloratadine
Online Access:http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2013;volume=5;issue=1;spage=74;epage=79;aulast=Hasnain

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http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2013;volume=5;issue=1;spage=74;epage=79;aulast=Hasnain

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