Derivation of Breast Cancer Cell Lines Under Physiological (5%) Oxygen Concentrations

Derivation of Breast Cancer Cell Lines Under Physiological (5%) Oxygen Concentrations

Background: Most human breast cancer cell lines currently in use were developed and are cultured under ambient (21%) oxygen conditions. While this is convenient in practical terms, higher ambient oxygen could increase oxygen radical production, potentially modulating signaling pathways. We have deri...

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Bibliographic Details
Main Authors: Euphemia Y. Leung, Marjan E. Askarian-Amiri, Dean C. Singleton, Carole Ferraro-Peyret, Wayne R. Joseph, Graeme J. Finlay, Reuben J. Broom, Purvi M. Kakadia, Stefan K. Bohlander, Elaine Marshall, Bruce C. Baguley
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Oncology
Subjects:
breast cancer
PI3K mTOR inhibitor BEZ235
estrogen receptor
HER2 inhibitors
5% and 21% oxygen
CA9
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00425/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00425/full

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