Shedding of APP limits its synaptogenic activity and cell adhesion properties

Shedding of APP limits its synaptogenic activity and cell adhesion properties

The Amyloid precursor protein (APP) plays a central role in Alzheimer’s disease (AD) and has essential synapse promoting functions. Synaptogenic activity as well as cell adhesion properties of APP presumably depend on trans-cellular dimerization via its extracellular domain. Since neuronal APP is ex...

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Bibliographic Details
Main Authors: Ronny eStahl, Sandra eSchilling, Peter eSoba, Carsten eRupp, Tobias eHartmann, Katja eWagner, Gunter eMerdes, Simone eEggert, Stefan eKins
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Cell Adhesion
Alzheimer's disease
amyloid precursor protein
APP
Sam
shedding
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00410/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00410/full

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