Optimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge
Highlights Cas9 RNA functions as a miRNA sponge. Let-7 is the dominant regulated miRNA by Cas9 RNA. RNA sequence optimization of Cas9 by synonymous mutation improves its safety.
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2022-06-01
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Series: | Molecular Cancer |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12943-022-01604-x |