Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis

Epigallocatechin-3-Gallate Prevents Acute Gout by Suppressing NLRP3 Inflammasome Activation and Mitochondrial DNA Synthesis

Gout is a chronic inflammatory disease evoked by the deposition of monosodium urate (MSU) crystals in joint tissues. The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome is responsible for the gout inflammatory symptoms induced...

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Bibliographic Details
Main Authors: Hye Eun Lee, Gabsik Yang, Youn Bum Park, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Molecules
Subjects:
inflammasome
gout
mitochondria
reactive oxygen species
green tea
macrophages
innate immunity
Online Access:https://www.mdpi.com/1420-3049/24/11/2138

Internet

https://www.mdpi.com/1420-3049/24/11/2138

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