Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes.

Glutamine deficiency induces DNA alkylation damage and sensitizes cancer cells to alkylating agents through inhibition of ALKBH enzymes.

Driven by oncogenic signaling, glutamine addiction exhibited by cancer cells often leads to severe glutamine depletion in solid tumors. Despite this nutritional environment that tumor cells often experience, the effect of glutamine deficiency on cellular responses to DNA damage and chemotherapeutic...

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Bibliographic Details
Main Authors: Thai Q Tran, Mari B Ishak Gabra, Xazmin H Lowman, Ying Yang, Michael A Reid, Min Pan, Timothy R O'Connor, Mei Kong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-11-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC5673162?pdf=render

Internet

http://europepmc.org/articles/PMC5673162?pdf=render

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