Optimizing Dacarbazine Therapy: Design of a Laser-Triggered Delivery System Based on β-Cyclodextrin and Plasmonic Gold Nanoparticles

Optimizing Dacarbazine Therapy: Design of a Laser-Triggered Delivery System Based on β-Cyclodextrin and Plasmonic Gold Nanoparticles

Dacarbazine (DB) is an antineoplastic drug extensively used in cancer therapy. However, present limitations on its performance are related to its low solubility, instability, and non-specificity. To overcome these drawbacks, DB was included in β-cyclodextrin (βCD), which increased its aqueous solubi...

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Bibliographic Details
Main Authors: Sebastián Quintana-Contardo, Orlando Donoso-González, Erika Lang, Ariel R. Guerrero, Michael Noyong, Ulrich Simon, Marcelo J. Kogan, Nicolás Yutronic, Rodrigo Sierpe
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Pharmaceutics
Subjects:
dacarbazine
β-cyclodextrin
gold nanoparticle
inclusion complex
drug delivery
laser irradiation
Online Access:https://www.mdpi.com/1999-4923/15/2/458

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https://www.mdpi.com/1999-4923/15/2/458

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