Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation

Inhibition of HMGB1/RAGE-mediated endocytosis by HMGB1 antagonist box A, anti-HMGB1 antibodies, and cholinergic agonists suppresses inflammation

Abstract Background Extracellular high mobility group box 1 protein  (HMGB1) serves a central role in inflammation as a transporter protein, which binds other immune-activating molecules that are endocytosed via the receptor for advanced glycation end-products (RAGE). These pro-inflammatory complexe...

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Bibliographic Details
Main Authors: Huan Yang, Hui Liu, Qiong Zeng, Gavin H. Imperato, Meghan E. Addorisio, Jianhua Li, Mingzhu He, Kai Fan Cheng, Yousef Al-Abed, Helena E. Harris, Sangeeta S. Chavan, Ulf Andersson, Kevin J. Tracey
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Molecular Medicine
Subjects:
Cytokine
LPS
HMGB1
RAGE
Endocytosis sepsis
Online Access:http://link.springer.com/article/10.1186/s10020-019-0081-6

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http://link.springer.com/article/10.1186/s10020-019-0081-6

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