Mitotic Maturation Compensates for Premature Centrosome Splitting and PCM Loss in Human <i>cep135</i> Knockout Cells

Centrosomes represent main microtubule organizing centers (MTOCs) in animal cells. Their duplication in S-phase enables the establishment of two MTOCs in M-phase that define the poles of the spindle and ensure equal distribution of chromosomes and centrosomes to the two daughter cells. While key fun...

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Bibliographic Details
Main Authors: Zhenzhen Chu, Oliver J. Gruss
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/11/7/1189