DMT1 Protects Macrophages from <i>Salmonella</i> Infection by Controlling Cellular Iron Turnover and Lipocalin 2 Expression

DMT1 Protects Macrophages from <i>Salmonella</i> Infection by Controlling Cellular Iron Turnover and Lipocalin 2 Expression

Macrophages are at the center of innate pathogen control and iron recycling. Divalent metal transporter 1 (DMT1) is essential for the uptake of non-transferrin-bound iron (NTBI) into macrophages and for the transfer of transferrin-bound iron from the endosome to the cytoplasm. As the control of cell...

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Bibliographic Details
Main Authors: Manuel Grander, Alexander Hoffmann, Markus Seifert, Egon Demetz, Philipp Grubwieser, Christa Pfeifhofer-Obermair, David Haschka, Günter Weiss
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
nutritional immunity
iron
DMT1
lipocalin 2
<i>Salmonella</i> Typhimurium
macrophage
Online Access:https://www.mdpi.com/1422-0067/23/12/6789

Internet

https://www.mdpi.com/1422-0067/23/12/6789

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