Combined Use of Cyclodextrins and Amino Acids for the Development of Cefixime Oral Solutions for Pediatric Use

Combined Use of Cyclodextrins and Amino Acids for the Development of Cefixime Oral Solutions for Pediatric Use

Cefixime (CEF) is a cephalosporin included in the WHO Model List of Essential Medicines for Children. Liquid formulations are considered the best choice for pediatric use, due to their great ease of administration and dose-adaptability. Owing to its very low aqueous solubility and poor stability, CE...

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Bibliographic Details
Main Authors: Marzia Cirri, Natascia Mennini, Giulia Nerli, Jessica Rubia, Enrico Casalone, Fabrizio Melani, Francesca Maestrelli, Paola Mura
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceutics
Subjects:
cefixime
amino acids
pediatric oral formulation
sulfobutylether-β-cyclodextrin
histidine
molecular dynamic studies
Online Access:https://www.mdpi.com/1999-4923/13/11/1923

Internet

https://www.mdpi.com/1999-4923/13/11/1923

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