Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy

Enzymatic Construction of DARPin-Based Targeted Delivery Systems Using Protein Farnesyltransferase and a Capture and Release Strategy

Protein-based conjugates have been extensively utilized in various biotechnological and therapeutic applications. In order to prepare homogeneous conjugates, site-specific modification methods and efficient purification strategies are both critical factors to be considered. The development of genera...

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Bibliographic Details
Main Authors: Yi Zhang, Yiao Wang, Safak Uslu, Sneha Venkatachalapathy, Mohammad Rashidian, Jonas V. Schaefer, Andreas Plückthun, Mark D. Distefano
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
protein farnesyltransferase
site-specific protein conjugation
biorthogonal conjugation
targeted drug delivery
Online Access:https://www.mdpi.com/1422-0067/23/19/11537

Internet

https://www.mdpi.com/1422-0067/23/19/11537

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