Preferential Antibody and Drug Conjugate Targeting of the ADAM10 Metalloprotease in Tumours

Preferential Antibody and Drug Conjugate Targeting of the ADAM10 Metalloprotease in Tumours

ADAM10 is a transmembrane metalloprotease that sheds a variety of cell surface proteins, including receptors and ligands that regulate a range of developmental processes which re-emerge during tumour development. While ADAM10 is ubiquitously expressed, its activity is normally tightly regulated, but...

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Bibliographic Details
Main Authors: Hengkang Yan, Mary E. Vail, Linda Hii, Nancy Guo, Paul J. McMurrick, Karen Oliva, Simon Wilkins, Nayanendu Saha, Dimitar B. Nikolov, Fook-Thean Lee, Andrew M. Scott, Peter W. Janes
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cancers
Subjects:
ADAM metalloprotease
therapeutic antibody
antibody–drug conjugate
colon cancer
brain cancer
Online Access:https://www.mdpi.com/2072-6694/14/13/3171

Internet

https://www.mdpi.com/2072-6694/14/13/3171

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