Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosis

Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosis

Antisense oligonucleotides (ASOs) against Ldl receptor (Ldlr-ASO) represent a promising strategy to promote hypercholesterolemic atherosclerosis in animal models without the need for complex breeding strategies. Here, we sought to characterize and contrast atherosclerosis in mice given Ldlr-ASO with...

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Bibliographic Details
Main Authors: Diego Gomes, Shari Wang, Leela Goodspeed, Katherine E. Turk, Tomasz Wietecha, Yongjun Liu, Karin E. Bornfeldt, Kevin D. O'Brien, Alan Chait, Laura J. den Hartigh
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Journal of Lipid Research
Subjects:
animal models
hyperlipidemia
inflammation
liver
receptors/lipoprotein
antisense oligonucleotides
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522000074

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http://www.sciencedirect.com/science/article/pii/S0022227522000074

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