Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma

Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma

Summary: The transition of neural progenitors to differentiated postmitotic neurons is mainly considered irreversible in physiological conditions. In the present work, we show that Shh pathway activation through SmoM2 expression promotes postmitotic neurons dedifferentiation, re-entering in the cell...

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Main Authors: Giuseppe Aiello, Claudio Ballabio, Riccardo Ruggeri, Luca Fagnocchi, Marica Anderle, Ilaria Morassut, Davide Caron, Francesca Garilli, Francesca Gianno, Felice Giangaspero, Silvano Piazza, Alessandro Romanel, Alessio Zippo, Luca Tiberi
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719315281

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http://www.sciencedirect.com/science/article/pii/S2211124719315281

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