Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma
Summary: The transition of neural progenitors to differentiated postmitotic neurons is mainly considered irreversible in physiological conditions. In the present work, we show that Shh pathway activation through SmoM2 expression promotes postmitotic neurons dedifferentiation, re-entering in the cell...
Main Authors: | Giuseppe Aiello, Claudio Ballabio, Riccardo Ruggeri, Luca Fagnocchi, Marica Anderle, Ilaria Morassut, Davide Caron, Francesca Garilli, Francesca Gianno, Felice Giangaspero, Silvano Piazza, Alessandro Romanel, Alessio Zippo, Luca Tiberi |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-12-01
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Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124719315281 |
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