Whole-exome sequencing reveals damaging gene variants associated with hypoalphalipoproteinemia

Whole-exome sequencing reveals damaging gene variants associated with hypoalphalipoproteinemia

Low levels of high density lipoprotein-cholesterol (HDL-C) are associated with an elevated risk of arteriosclerotic coronary heart disease. Heritability of HDL-C levels is high. In this research discovery study, we used whole-exome sequencing to identify damaging gene variants that may play signific...

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Bibliographic Details
Main Authors: Weilai Dong, Karen H.Y. Wong, Youbin Liu, Michal Levy-Sakin, Wei-Chien Hung, Mo Li, Boyang Li, Sheng Chih Jin, Jungmin Choi, Francesc Lopez-Giraldez, Dedeepya Vaka, Annie Poon, Catherine Chu, Richard Lao, Melek Balamir, Irina Movsesyan, Mary J. Malloy, Hongyu Zhao, Pui-Yan Kwok, John P. Kane, Richard P. Lifton, Clive R. Pullinger
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Journal of Lipid Research
Subjects:
dyslipidemia
genetics
HDL
LDL
lipoproteins
prebeta-1 HDL
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522000426

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http://www.sciencedirect.com/science/article/pii/S0022227522000426

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