Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor

Structure insights into selective coupling of G protein subtypes by a class B G protein-coupled receptor

Here, the authors report structures of corticotropin releasing factor receptor 2 (CRF2R) bound to agonist Urocortin 1 (UCN1) and coupled to G proteins G11 and Go, offering insight into the structural basis for the ability of CRF2R to couple with multiple G protein subtypes.

Bibliographic Details
Main Authors: Li-Hua Zhao, Jingyu Lin, Su-Yu Ji, X. Edward Zhou, Chunyou Mao, Dan-Dan Shen, Xinheng He, Peng Xiao, Jinpeng Sun, Karsten Melcher, Yan Zhang, Xiao Yu, H. Eric Xu
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-33851-3

Internet

https://doi.org/10.1038/s41467-022-33851-3

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