USP7 promotes the osteoclast differentiation of CD14+ human peripheral blood monocytes in osteoporosis via HMGB1 deubiquitination

USP7 promotes the osteoclast differentiation of CD14+ human peripheral blood monocytes in osteoporosis via HMGB1 deubiquitination

Background: Abnormal osteoclast and osteoblast differentiation is an essential pathological process in osteoporosis. As an important deubiquitinase enzyme, ubiquitin-specific peptidase 7 (USP7) participates in various disease processes through posttranslational modification. However, the mechanism b...

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Bibliographic Details
Main Authors: Yu-Cong Lin, Guan Zheng, Hua-Tao Liu, Peng Wang, Wei-Quan Yuan, Yun-Hui Zhang, Xiao-Shuai Peng, Guo-Jian Li, Yan-Feng Wu, Hui-Yong Shen
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Journal of Orthopaedic Translation
Subjects:
USP7
Osteoporosis
Osteoclast differentiation
Deubiquitination
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X23000347

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http://www.sciencedirect.com/science/article/pii/S2214031X23000347

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