Drug screening for autophagy inhibitors based on the dissociation of Beclin1-Bcl2 complex using BiFC technique and mechanism of eugenol on anti-influenza A virus activity.

Drug screening for autophagy inhibitors based on the dissociation of Beclin1-Bcl2 complex using BiFC technique and mechanism of eugenol on anti-influenza A virus activity.

Autophagy is involved in many human diseases, such as cancer, cardiovascular disease and virus infection, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), influenza A virus (IAV) and coxsackievirus B3/B4 (CVB3/B4), so a drug screening model targeting autophagy may be very usefu...

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Bibliographic Details
Main Authors: Jian-Ping Dai, Xiang-Feng Zhao, Jun Zeng, Qian-Ying Wan, Jia-Cai Yang, Wei-Zhong Li, Xiao-Xuan Chen, Ge-Fei Wang, Kang-Sheng Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3628889?pdf=render

Internet

http://europepmc.org/articles/PMC3628889?pdf=render

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