Congenital diaphragmatic hernias: from genes to mechanisms to therapies

Congenital diaphragmatic hernias: from genes to mechanisms to therapies

Congenital diaphragmatic hernias (CDHs) and structural anomalies of the diaphragm are a common class of congenital birth defects that are associated with significant morbidity and mortality due to associated pulmonary hypoplasia, pulmonary hypertension and heart failure. In ∼30% of CDH patients, gen...

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Bibliographic Details
Main Authors: Gabrielle Kardon, Kate G. Ackerman, David J. McCulley, Yufeng Shen, Julia Wynn, Linshan Shang, Eric Bogenschutz, Xin Sun, Wendy K. Chung
Format: Article
Language:English
Published: The Company of Biologists 2017-08-01
Series:Disease Models & Mechanisms
Subjects:
Structural birth defects
Congenital diaphragmatic hernia (CDH)
Diaphragm
Pulmonary hypoplasia
Pulmonary hypertension
Congenital heart disease (CHD)
Genetics
Online Access:http://dmm.biologists.org/content/10/8/955

Internet

http://dmm.biologists.org/content/10/8/955

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