Carbenoxolone Blocks Endotoxin-Induced Protein Kinase R (PKR) Activation and High Mobility Group Box 1 (HMGB1) Release

Carbenoxolone Blocks Endotoxin-Induced Protein Kinase R (PKR) Activation and High Mobility Group Box 1 (HMGB1) Release

Abstract The pathogen- and damage-associated molecular patterns (for example, bacterial endotoxin and adenosine 5′-triphosphate (ATP)) activate the double-stranded RNA-activated protein kinase R (PKR) to trigger the inflammasome-dependent high mobility group box 1 (HMGB1) release. Extracellular ATP...

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Bibliographic Details
Main Authors: Wei Li, Jianhua Li, Andrew E. Sama, Haichao Wang
Format: Article
Language:English
Published: BMC 2013-07-01
Series:Molecular Medicine
Subjects:
High Mobility Group Box (HMGB1)
HMGB1 Release
P2X7R Antagonists
Purinergic P2X7 Receptor (P2X7R)
HMGB1 Levels
Online Access:https://doi.org/10.2119/molmed.2013.00064

Internet

https://doi.org/10.2119/molmed.2013.00064

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