A versatile δ-aminolevulinic acid (ΑLA)-cyclodextrin bimodal conjugate-prodrug for PDT applications with the help of intracellular chemistry

A versatile δ-aminolevulinic acid (ΑLA)-cyclodextrin bimodal conjugate-prodrug for PDT applications with the help of intracellular chemistry

Grafting of δ-aminolevulinic acid (1) moieties on the narrow periphery of a β-cyclodextrin (β-CD) derivative through hydrolysable bonds was implemented, in order to generate a water-soluble, molecular/drug carrier with the capacity to undergo intracellular transformation into protoporphyrin IX (PpIX...

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Bibliographic Details
Main Authors: Chrysie Aggelidou, Theodossis A. Theodossiou, Antonio Ricardo Gonçalves, Mariza Lampropoulou, Konstantina Yannakopoulou
Format: Article
Language:English
Published: Beilstein-Institut 2014-10-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
cyclodextrins
PDT
protoporphyrin IX
prodrug
δ-aminolevulinic acid
Online Access:https://doi.org/10.3762/bjoc.10.251

Internet

https://doi.org/10.3762/bjoc.10.251

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