Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma

Melatonin Treatment Triggers Metabolic and Intracellular pH Imbalance in Glioblastoma

Metabolic rewiring in glioblastoma (GBM) is linked to intra- and extracellular pH regulation. In this study, we sought to characterize the role of melatonin on intracellular pH modulation and metabolic consequences to identify the mechanisms of action underlying melatonin oncostatic effects on GBM t...

Full description

Bibliographic Details
Main Authors: Beatriz I. Fernandez-Gil, Andrea Otamendi-Lopez, Alexandra Bechtle, Carla A. Vazquez-Ramos, Neda Qosja, Paola Suarez-Meade, Rachel Sarabia-Estrada, Mark E. Jentoft, Hugo Guerrero-Cázares, Germaine Escames, Paula Schiapparelli, Alfredo Quiñones-Hinojosa
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
intracellular acidity
cancer metabolism
lactate
MCT4
ROS
LDHA
Online Access:https://www.mdpi.com/2073-4409/11/21/3467

Internet

https://www.mdpi.com/2073-4409/11/21/3467

Similar Items