MALT-1 shortens lifespan by inhibiting autophagy in the intestine of C. elegans

MALT-1 shortens lifespan by inhibiting autophagy in the intestine of C. elegans

ABSTRACTThe caspase-like protease MALT1 promotes immune responses and oncogenesis in mammals by activating the transcription factor NF-κB. MALT1 is remarkably conserved from mammals to simple metazoans devoid of NF-κB homologs, like the nematode C. elegans. To discover more ancient, NF-κB -independe...

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Bibliographic Details
Main Authors: Julie Vérièpe-Salerno, Silvia Podavini, Marcus J.C. Long, Irina Kolotuev, Muriel Cuendet, Margot Thome
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Autophagy Reports
Subjects:
Aging
autolysosome
autophagosome
Beclin-1
chloroquine
electron microscopy
Online Access:https://www.tandfonline.com/doi/10.1080/27694127.2023.2277584

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https://www.tandfonline.com/doi/10.1080/27694127.2023.2277584

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