Small Molecule Inhibitors of Wnt/β-Catenin/Lef-1 Signaling Induces Apoptosis in Chronic Lymphocytic Leukemia Cells In Vitro and In Vivo

Small Molecule Inhibitors of Wnt/β-Catenin/Lef-1 Signaling Induces Apoptosis in Chronic Lymphocytic Leukemia Cells In Vitro and In Vivo

BACKGROUND: Lymphoid enhancer factor-1 (lef-1) is overexpressed in B-cell chronic lymphocytic leukemia (CLL) when compared with normal B cells and transcribes several genes implicated in the pathogenesis of CLL. We therefore hypothesize that antagonism of lef-1 might lead to killing of CLL cells. We...

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Bibliographic Details
Main Authors: Rajesh Kumar Gandhirajan, Peter Anton Staib, Katharina Minke, Iris Gehrke, Günther Plickert, Axel Schlösser, Esther Katharina Schmitt, Michael Hallek, Karl-Anton Kreuzer
Format: Article
Language:English
Published: Elsevier 2010-04-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558610800119

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http://www.sciencedirect.com/science/article/pii/S1476558610800119

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