Kremen2 drives the progression of non-small cell lung cancer by preventing SOCS3-mediated degradation of EGFR

Kremen2 drives the progression of non-small cell lung cancer by preventing SOCS3-mediated degradation of EGFR

Abstract Background The transmembrane receptor Kremen2 has been reported to participate in the tumorigenesis and metastasis of gastric cancer. However, the role of Kremen2 in non-small cell lung cancer (NSCLC) and the underlying mechanism remain unclear. This study aimed to explore the biological fu...

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Bibliographic Details
Main Authors: Yuxiao Sun, Yu Gao, Mingxin Dong, Jiuzhen Li, Xin Li, Ningning He, Huijuan Song, Manman Zhang, Kaihua Ji, Jinhan Wang, Yeqing Gu, Yan Wang, Liqing Du, Yang Liu, Qin Wang, Hezheng Zhai, Daqiang Sun, Qiang Liu, Chang Xu
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Kremen2
Non-small cell lung cancer
EGFR
SOCS3
Ubiquitination
Online Access:https://doi.org/10.1186/s13046-023-02692-3

Internet

https://doi.org/10.1186/s13046-023-02692-3

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