The Streptococcus virulence protein PepO triggers anti-tumor immune responses by reprograming tumor-associated macrophages in a mouse triple negative breast cancer model

The Streptococcus virulence protein PepO triggers anti-tumor immune responses by reprograming tumor-associated macrophages in a mouse triple negative breast cancer model

Abstract Background The efficacy of current surgery and chemotherapy for triple negative breast cancer (TNBC) is limited due to heterogenous and immunosuppressive tumor microenvironment (TME). Tumor associated macrophages (TAMs), which are regarded as an M2 tumor-promoting phenotype, are crucial in...

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Bibliographic Details
Main Authors: Bichen Liu, Jun Huang, Jiangming Xiao, Wenlong Xu, Hong Zhang, Yuan Yuan, Yibing Yin, Xuemei Zhang
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cell & Bioscience
Subjects:
Streptococcus pneumoniae endopeptidase O(PepO)
Triple negative breast cancer (TNBC)
Tumor associated macrophages reprograming
Tumor microenvironment
Cancer immunotherapy
Immunoregulatory molecule
Online Access:https://doi.org/10.1186/s13578-023-01153-w

Internet

https://doi.org/10.1186/s13578-023-01153-w

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