Applying fluorescent dye assays to discriminate Escherichia coli chlorhexidine resistance phenotypes from porin and mlaA deletions and efflux pumps

Applying fluorescent dye assays to discriminate Escherichia coli chlorhexidine resistance phenotypes from porin and mlaA deletions and efflux pumps

Abstract Bacterial resistance to the antiseptic chlorhexidine (CHX), is a growing problem, recently shown to be caused by deleterious mutations to the phospholipid transport system component (mlaA) as well as efflux pump overexpression. Comparisons of CHX resistance mechanisms, such as porin deletio...

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Bibliographic Details
Main Authors: Branden S. J. Gregorchuk, Shelby L. Reimer, Carmine J. Slipski, Kieran A. Milner, Shannon L. Hiebert, Daniel R. Beniac, Timothy F. Booth, George G. Zhanel, Denice C. Bay
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15775-6

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https://doi.org/10.1038/s41598-022-15775-6

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