Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci

Castration delays epigenetic aging and feminizes DNA methylation at androgen-regulated loci

In mammals, females generally live longer than males. Nevertheless, the mechanisms underpinning sex-dependent longevity are currently unclear. Epigenetic clocks are powerful biological biomarkers capable of precisely estimating chronological age and identifying novel factors influencing the aging ra...

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Bibliographic Details
Main Authors: Victoria J Sugrue, Joseph Alan Zoller, Pritika Narayan, Ake T Lu, Oscar J Ortega-Recalde, Matthew J Grant, C Simon Bawden, Skye R Rudiger, Amin Haghani, Donna M Bond, Reuben R Hore, Michael Garratt, Karen E Sears, Nan Wang, Xiangdong William Yang, Russell G Snell, Timothy A Hore, Steve Horvath
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-07-01
Series:eLife
Subjects:
castration
epigenetic clock
DNA methylation
sheep
aging
androgens
Online Access:https://elifesciences.org/articles/64932

Internet

https://elifesciences.org/articles/64932

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