Rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse.
The neuroendocrine and metabolic effects of leptin have been extensively researched since the discovery, and the later identification, of the leptin gene mutated within the ob/ob mouse. Leptin is required for optimal health in a number of physiological systems (e.g. fertility, bone density, body wei...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3176308?pdf=render |
| _version_ | 1819064741618778112 |
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| author | Deanna Marie Arble Martha Hotz Vitaterna Fred W Turek |
| author_facet | Deanna Marie Arble Martha Hotz Vitaterna Fred W Turek |
| author_sort | Deanna Marie Arble |
| collection | DOAJ |
| description | The neuroendocrine and metabolic effects of leptin have been extensively researched since the discovery, and the later identification, of the leptin gene mutated within the ob/ob mouse. Leptin is required for optimal health in a number of physiological systems (e.g. fertility, bone density, body weight regulation). Despite the extensive leptin literature and many observations of leptin's cyclical pattern over the 24-hour day, few studies have specifically examined how the circadian rhythm of leptin may be essential to leptin signaling and health. Here we present data indicating that a rhythmic leptin profile (e.g. 1 peak every 24 hours) leads to excessive weight gain during desynchronized feeding whereas non-rhythmic leptin provided in a continuous manner does not lead to excessive body weight gain under similar feeding conditions. This study suggests that feeding time can interact with leptin's endogenous rhythm to influence metabolic signals, specifically leading to excessive body weight gains during 'wrongly' timed feeding. |
| first_indexed | 2024-12-21T15:35:23Z |
| format | Article |
| id | doaj.art-901f3ee9fd04448d86b92d80b5278682 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T15:35:23Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-901f3ee9fd04448d86b92d80b52786822022-12-21T18:58:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0169e2507910.1371/journal.pone.0025079Rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse.Deanna Marie ArbleMartha Hotz VitaternaFred W TurekThe neuroendocrine and metabolic effects of leptin have been extensively researched since the discovery, and the later identification, of the leptin gene mutated within the ob/ob mouse. Leptin is required for optimal health in a number of physiological systems (e.g. fertility, bone density, body weight regulation). Despite the extensive leptin literature and many observations of leptin's cyclical pattern over the 24-hour day, few studies have specifically examined how the circadian rhythm of leptin may be essential to leptin signaling and health. Here we present data indicating that a rhythmic leptin profile (e.g. 1 peak every 24 hours) leads to excessive weight gain during desynchronized feeding whereas non-rhythmic leptin provided in a continuous manner does not lead to excessive body weight gain under similar feeding conditions. This study suggests that feeding time can interact with leptin's endogenous rhythm to influence metabolic signals, specifically leading to excessive body weight gains during 'wrongly' timed feeding.http://europepmc.org/articles/PMC3176308?pdf=render |
| spellingShingle | Deanna Marie Arble Martha Hotz Vitaterna Fred W Turek Rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse. PLoS ONE |
| title | Rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse. |
| title_full | Rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse. |
| title_fullStr | Rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse. |
| title_full_unstemmed | Rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse. |
| title_short | Rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse. |
| title_sort | rhythmic leptin is required for weight gain from circadian desynchronized feeding in the mouse |
| url | http://europepmc.org/articles/PMC3176308?pdf=render |
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