Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase.

Unexpected neuronal protection of SU5416 against 1-Methyl-4-phenylpyridinium ion-induced toxicity via inhibiting neuronal nitric oxide synthase.

SU5416 was originally designed as a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) for cancer therapy. In this study, we have found for the first time that SU5416 unexpectedly prevented 1-methyl-4-phenylpyridinium ion (MPP(+))-induced neuronal apoptosis in...

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Bibliographic Details
Main Authors: Wei Cui, Zaijun Zhang, Wenming Li, Shinghung Mak, Shengquan Hu, Huan Zhang, Shuai Yuan, Jianhui Rong, Tony Chunglit Choi, Simon M Y Lee, Yifan Han
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3457988?pdf=render

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http://europepmc.org/articles/PMC3457988?pdf=render

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