RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1

RSPO3 impairs barrier function of human vascular endothelial monolayers and synergizes with pro-inflammatory IL-1

Abstract Background Endothelial barrier dysfunction characterized by hyperpermeability of the vascular endothelium is a key factor in the pathogenesis of chronic inflammatory diseases and affects clinical outcomes. In states of chronic inflammation, mediators secreted by activated immune cells or va...

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Bibliographic Details
Main Authors: Tom Skaria, Esther Bachli, Gabriele Schoedon
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Molecular Medicine
Subjects:
Endothelial dysfunction
RSPO3
Inflammation
Vascular leakage
IL-1β
Online Access:http://link.springer.com/article/10.1186/s10020-018-0048-z

Internet

http://link.springer.com/article/10.1186/s10020-018-0048-z

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